A 25-gene classifier predicts overall survival in resectable pancreatic cancer

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A 25-gene classifier predicts overall survival in resectable pancreatic cancer

BACKGROUND Pancreatic carcinoma is one of the most lethal human cancers. In patients with resectable tumors, surgery followed by adjuvant chemotherapy is the only curative treatment. However, the 5-year survival is 20%. Because of a strong metastatic propensity, neoadjuvant chemotherapy is being tested in randomized clinical trials. In this context, improving the selection of patients for immed...

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Author’s response to reviews Title: A 25-gene classifier predicts overall survival in resectable pancreatic cancer Authors:

Title: A 25-gene classifier predicts overall survival in resectable pancreatic cancer Authors: David Birnbaum ([email protected]) Pascal Finetti ([email protected]) Alexia Lopresti ([email protected]) Marine Gilabert ([email protected]) Flora Poizat ([email protected]) Jean-Luc Raoul ([email protected]) Jean-Robert Delpero ([email protected]...

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Systemic Immune Activity Predicts Overall Survival in Treatment-Naïve Patients with Metastatic Pancreatic Cancer.

PURPOSE Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate <7% and is ultimately refractory to most treatments. To date, an assessment of immunologic factors relevant to disease has not been comprehensively performed for treatment-naïve patients. We hypothesized that systemic immunologic biomarkers could predict overall survival (OS) in treatment-naïve P...

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A circulating TH2 cytokines profile predicts survival in patients with resectable pancreatic adenocarcinoma

Surgery is the only potentially curative option for patients with pancreatic ductal adenocarcinoma (PDAC), but metastatic relapse remains common. We hypothesized that the expression levels of inflammatory cytokines could predict recurrence of PDAC, thus allowing to select patients who most likely could benefit from surgical resection. We prospectively collected plasma at diagnosis from 287 pati...

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The concentration of D-dimers in portal blood positively correlates with overall survival in patients with non-resectable pancreatic cancer

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ژورنال

عنوان ژورنال: BMC Medicine

سال: 2017

ISSN: 1741-7015

DOI: 10.1186/s12916-017-0936-z